Additional Transplantation Research Studies Being Conducted by the ITN

TEACH - Alemtuzumab, Costimulation Blockade And Sirolimus: A Tolerogenic Canvas For Donor Antigen Delivery Via MSC

A study to determine whether cells from the kidney donor’s bone marrow, called mesenchymal stromal cells (MSCs), along with anti-rejection medications, will allow the immune system to tolerate the new kidney. 

LITTMUS - Liver Transplantation with Tregs Consortium

A clinical study testing a new approach using T regulatory cells to possibly stop anti-rejection medications after liver transplantation.

ALLTOL - Allograft Tolerance Study

An observational clinical study to learn more about tolerance in liver and kidney transplantation.

OPTIMAL - Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation

A clinical study investigating immunosuppression withdrawal in liver transplant recipients.

ACCEPTOR – Bone Marrow Transplantation and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance.

A study to assess the ability of a specialized pre-transplant conditioning regimen, bone marrow transplantation and high dose post-transplant cyclophosphamide, to induce tolerance and enable long-term discontinuation of immunosuppression in kidney transplant recipients.

RESTARRT – Research Study of ATG and Rituximab in Renal Transplantation.

A clinical trial testing whether a combination of anti-thymocyte globulin (ATG), rituximab, mycophenolate mofetil, tacrolimus and sirolimus can reset the immune system of kidney transplant recipients to help it accept the transplanted kidney without the need for life-long immunosuppression.

If you are interested in learning about other transplantation studies, we suggest that you visit clinicaltrials.gov for a list of additional clinical trials that are seeking volunteers.

For more information about the ITN and other clinical trials, please visit immunetolerance.org.